Virtual Microscopy	Choose another topic Cardiovascular Respiratory Renal and Urinary Tract Musculoskeletal Neuro(CNS and PNS) Gastrointestinal Reproductive Endocrine Hematopoiesis and Lymphoid Skin

Case 1: Germinal Cell Aplasia

A 30-year-old male and his wife had a history of infertility. The examination of the wife was unremarkable. The patient had small testes. A testis biopsy was performed.

Photomicrograph: [biopsy]

1. Identify the seminiferous tubules, interstitium, and Leydig cells.
2. What cells comprise the seminiferous tubules? What cells are missing?
3. What indicates that patient is post pubertal?
4. What would you expect the semen analysis to demonstrate?
5. What would you expect the opposite testis to show?

Case 2: Benign Prostatic Hypertrophy

A 61 year old man developed increased frequency of urination, nocturia, urgency, and hesitancy.

Photomicrograph: [prostate 1] [prostate 2]

1. Does this patient most likely have bladder cancer?
2. Should a prostate biopsy be performed immediately?
3. What part of the prostate gland might be involved?

Case 3

A 35-year-old male and his wife had a two-year history of infertility. The examination of the wife yielded no functional or anatomic abnormalities. The patient had a semen analysis that contained no spermatozoa. A testis biopsy was performed.

Photomicrograph: [biopsy] [testis]

1. What cells are identifiable in the seminiferous tubules?
2. How does the histology of this testis differ from that of case #1?
3. Why doesn't the semen contain spermatozoa?